Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Career Basics

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 28 August 2007
Vol. 2007, Issue 401, p. tw313
[DOI: 10.1126/stke.4012007tw313]

EDITORS' CHOICE

Neuroscience Astrocytes at Single Synapses

Peter Stern

Science, AAAS, Cambridge CB2 1LQ, UK

Astrocytes respond to synaptic activity and can release different gliotransmitters, which modulate neuronal activity and neurotransmission. Perea and Araque examined the role of astrocytes on synaptic transmission at single hippocampal excitatory synapses. Ca2+ elevation in astrocytes led to a transient release of the neurotransmitter glutamate from astrocytes, which was mediated by metabotropic glutamate receptors. Potentiation became long-lasting when glial activation was paired with postsynaptic depolarization.

G. Perea, A. Araque, Astrocytes potentiate transmitter release at single hippocampal synapses. Science 317, 1083-1086 (2007). [Abstract] [Full Text]

Citation: P. Stern, Astrocytes at Single Synapses. Sci. STKE 2007, tw313 (2007).

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)