Adenylyl Cyclase 5: A New Clue in the Search for the "Fountain of Youth"?
Julia A. Chester1 and
Val J. Watts2*
1Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA.
2Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Abstract:
The adenylyl cyclase (AC)–cyclic adenosine monophosphate (cAMP) signaling pathway is involved in a number of important physiological functions in both the peripheral and central nervous systems. A report now indicates that genetic disruption of AC5 increases mouse life span and confers resistance to aging-related conditions, including bone loss and cardiomyopathies. It is proposed that these beneficial effects may be the result of the increased activity of second messenger signaling proteins such as mitogen-activated or extracellular signal–regulated protein kinase kinase (MAPKK, also known as MEK) and extracellular signal–regulated kinase (ERK), or of enzymes such as manganese superoxide dismutase (MnSOD) that promote cell survival through protection against oxidative stress and apoptosis. These intriguing findings should stimulate additional research aimed at dissecting the complex cellular mechanisms regulated by AC isoforms and may lead to novel genetic and pharmacological approaches to delay aging-related conditions and to extend life span.
*Corresponding author. E-mail, wattsv{at}purdue.edu
