Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Signal., 16 February 2010
Vol. 3, Issue 109, p. cm3
[DOI: 10.1126/scisignal.3109cm3]

CONNECTIONS MAP OVERVIEWS

Jasmonate Biochemical Pathway

Aurélie Gfeller1, Lucie Dubugnon2, Robin Liechti3, and Edward E. Farmer1*

1 Current contributing authorities, Gene Expression Laboratory, Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, Biophore, CH-1015 Lausanne, Switzerland.
2 Former contributing authority, Institut de Chimie Clinique, CH-1002 Lausanne, Switzerland.
3 Former contributing authority, Swiss Institute of Bioinformatics, Vital-IT Group, Génopode, CH-1015 Lausanne, Switzerland.

Abstract: Plants possess a family of potent fatty acid–derived wound-response and developmental regulators: the jasmonates. These compounds are derived from the tri-unsaturated fatty acids {alpha}-linolenic acid (18:3) and, in plants such as Arabidopsis thaliana and tomato, 7(Z)-, 10(Z)-, and 13(Z)-hexadecatrienoic acid (16:3). The lipoxygenase-catalyzed addition of molecular oxygen to {alpha}-linolenic acid initiates jasmonate synthesis by providing a 13-hydroperoxide substrate for formation of an unstable allene oxide by allene oxide synthase (AOS). This allene oxide then undergoes enzyme-guided cyclization to produce 12-oxophytodienoic acid (OPDA). These first steps take place in plastids, but further OPDA metabolism occurs in peroxisomes. OPDA has several fates, including esterification into plastid lipids and transformation into the 12-carbon prohormone jasmonic acid (JA). JA is itself a substrate for further diverse modifications, including the production of jasmonoyl-isoleucine (JA-Ile), which is a major biologically active jasmonate among a growing number of jasmonate derivatives. Each new jasmonate family member that is discovered provides another key to understanding the fine control of gene expression in immune responses; in the initiation and maintenance of long-distance signal transfer in response to wounding; in the regulation of fertility; and in the turnover, inactivation, and sequestration of jasmonates, among other processes.

* Corresponding author. E-mail, edward.farmer{at}unil.ch

Citation: A. Gfeller, L. Dubugnon, R. Liechti, E. E. Farmer, Jasmonate Biochemical Pathway. Sci. Signal. 3, cm3 (2010).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Control of final organ size by Mediator complex subunit 25 in Arabidopsis thaliana.
R. Xu and Y. Li (2011)
Development 138, 4545-4554
   Abstract »    Full Text »    PDF »
Ectopic Expression of AtJMT in Nicotiana attenuata: Creating a Metabolic Sink Has Tissue-Specific Consequences for the Jasmonate Metabolic Network and Silences Downstream Gene Expression.
M. Stitz, K. Gase, I. T. Baldwin, and E. Gaquerel (2011)
Plant Physiology 157, 341-354
   Abstract »    Full Text »    PDF »
White Lupin Cluster Root Acclimation to Phosphorus Deficiency and Root Hair Development Involve Unique Glycerophosphodiester Phosphodiesterases.
L. Cheng, B. Bucciarelli, J. Liu, K. Zinn, S. Miller, J. Patton-Vogt, D. Allan, J. Shen, and C. P. Vance (2011)
Plant Physiology 156, 1131-1148
   Abstract »    Full Text »    PDF »
Cell Wall Damage-Induced Lignin Biosynthesis Is Regulated by a Reactive Oxygen Species- and Jasmonic Acid-Dependent Process in Arabidopsis.
L. Denness, J. F. McKenna, C. Segonzac, A. Wormit, P. Madhou, M. Bennett, J. Mansfield, C. Zipfel, and T. Hamann (2011)
Plant Physiology 156, 1364-1374
   Abstract »    Full Text »    PDF »
Lipoxygenase-mediated Oxidation of Polyunsaturated N-Acylethanolamines in Arabidopsis.
A. Kilaru, C. Herrfurth, J. Keereetaweep, E. Hornung, B. J. Venables, I. Feussner, and K. D. Chapman (2011)
J. Biol. Chem. 286, 15205-15214
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882