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Sci. Signal., 22 June 2010
Vol. 3, Issue 127, p. eg4
[DOI: 10.1126/scisignal.3127eg4]


(R)evolution of Complex Regulatory Systems

Rune Linding*

Cellular and Molecular Logic Team, Section of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.

Abstract: Signaling systems are exciting to study precisely because they are some of the most complex and dynamical systems that we know. The cell needs operational freedom and, thus, many motif-domain interactions might not be "hard-wired" through evolution, but instead may be like the Linux operating system, where symbolic links can point to files without duplication.

* Corresponding author. E-mail, linding{at}

Citation: R. Linding, (R)evolution of Complex Regulatory Systems. Sci. Signal. 3, eg4 (2010).

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Mutational properties of amino acid residues: implications for evolvability of phosphorylatable residues.
P. Creixell, E. M. Schoof, C. S. H. Tan, and R. Linding (2012)
Phil Trans R Soc B 367, 2584-2593
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