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Sci. Signal., 10 August 2010
Vol. 3, Issue 134, p. pe25
[DOI: 10.1126/scisignal.3134pe25]


B Cell Receptor Signaling: Picky About PI3Ks

Jose J. Limon and David A. Fruman*

Department of Molecular Biology and Biochemistry and Center for Immunology, University of California, Irvine, CA 92697, USA.

Abstract: The B cell receptor (BCR) and the pre-BCR control cell fate at many stages of B cell development, survival, and antigen response. Most of these processes require the activation of phosphatidylinositol 3-kinase (PI3K). Previous work has pointed to p110{delta} as the key catalytic isoform of PI3K for many B cell responses. A study of mice with different combinations of PI3K mutations confirms the central role of p110{delta} in agonist-mediated signaling, while identifying an unexpected function for the p110{alpha} isoform in tonic signaling by the pre-BCR and mature BCR.

* Corresponding author. E-mail, dfruman{at}

Citation: J. J. Limon, D. A. Fruman, B Cell Receptor Signaling: Picky About PI3Ks. Sci. Signal. 3, pe25 (2010).

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