Focus Issue: Systems Analysis of Protein Phosphorylation

Nancy R. Gough^1* and John F. Foley²

¹ Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
² Associate Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: Kinases and phosphatases are key regulatory molecules that participate in most cell signaling pathways. Systems-level analyses are providing new insights into phosphorylation sites and kinase specificity, and phosphoproteomic analyses are creating not just a wealth of data, but are also revealing rich revelations about cellular behavior, cellular responses to changing environmental conditions, and mechanisms of disease. Phosphatases are not merely signal terminators, but play active roles in signal transduction and are especially important in redox signaling. In this Focus Issue, Science Signaling highlights protein phosphorylation as the center of the signaling universe.

* Corresponding author. E-mail, ngough{at}aaas.org

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH RESOURCES
Systems Biology
Elucidating Human Phosphatase-Substrate Networks

Xun Li, Matthias Wilmanns, Janet Thornton, and Maja Köhn (14 May 2013)
Sci. Signal. 6 (275), rs10. [DOI: 10.1126/scisignal.2003203]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH RESOURCES
DNA Damage
Comparative Phosphoproteomic Analysis of Checkpoint Recovery Identifies New Regulators of the DNA Damage Response

Vincentius A. Halim, Mónica Alvarez-Fernández, Yan Juan Xu, Melinda Aprelia, Henk W. P. van den Toorn, Albert J. R. Heck, Shabaz Mohammed, and René H. Medema (23 April 2013)
Sci. Signal. 6 (272), rs9. [DOI: 10.1126/scisignal.2003664]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

MEETING REPORTS
Evolution
Sequence, Structure, and Network Evolution of Protein Phosphorylation

Chris Soon Heng Tan (19 July 2011)
Sci. Signal. 4 (182), mr6. [DOI: 10.1126/scisignal.2002093]
 |  Abstract »  |  Full Text »  |  PDF »

EDITORIAL GUIDES
Scientific Communication
Focus Issue: Conquering the Data Mountain

Nancy R. Gough and Michael B. Yaffe (15 February 2011)
Sci. Signal. 4 (160), eg2. [DOI: 10.1126/scisignal.2001871]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH RESOURCES
Phosphoproteomics
ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

Ariel Bensimon, Alexander Schmidt, Yael Ziv, Ran Elkon, Shih-Ya Wang, David J. Chen, Ruedi Aebersold, and Yosef Shiloh (7 December 2010)
Sci. Signal. 3 (151), rs3. [DOI: 10.1126/scisignal.2001034]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES: