Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 7 September 2010
Vol. 3, Issue 138, p. pe29
NF-B: Much Learned, Much to Learn
Bahram Razani1,2 and
1 Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 609 Charles E. Young Drive East, Los Angeles, CA 90095, USA. 2 Medical Scientist Training Program, David Geffen School of Medicine at the University of California Los Angeles, 23-385 Center for the Health Sciences, Box 957041/MC:704117, Los Angeles, CA 90095, USA.
Although NF-B (nuclear factor B) was discovered less than 25 years ago, it is one of the most well-studied transcription factors. It plays critical roles in various immune and cellular processes, and its dysregulation is a major driver of cancer and inflammatory pathology. A new book published by Cold Spring Harbor Laboratory Press, NF-B: A Network Hub Controlling Immunity, Inflammation, and Cancer, provides a series of excellent reviews on the architecture, regulation, and pathophysiological roles of NF-B signaling by some of the leading investigators in the field.