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Sci. Signal., 14 September 2010
Vol. 3, Issue 139, p. pe30
[DOI: 10.1126/scisignal.3139pe30]


Domain Recombination: A Workhorse for Evolutionary Innovation

Gordana Apic1,2 and Robert B. Russell2*

1 Cambridge Cell Networks, St John’s Innovation Centre, Cowley Road, Cambridge CB4 0WS, UK.
2 Cell Networks, Bioquant, University of Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.

Abstract: Although the combination of modular domains within proteins has been proposed as a determining feature of evolutionary innovation and flexibility, direct evidence for this mechanism of evolution has been sketchy. Two papers, one creating new domain combinations in the yeast mating pathway and another involving a comprehensive analysis of protein function and domain architecture across major organisms, have provided firm evidence that the recombining of domains can lead to evolutionary innovation. The results will guide future studies in synthetic and evolutionary biology.

* Corresponding author. E-mail, robert.russell{at}

Citation: G. Apic, R. B. Russell, Domain Recombination: A Workhorse for Evolutionary Innovation. Sci. Signal. 3, pe30 (2010).

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A Pluralistic Account of Homology: Adapting the Models to the Data.
L. S. Haggerty, P.-A. Jachiet, W. P. Hanage, D. A. Fitzpatrick, P. Lopez, M. J. O'Connell, D. Pisani, M. Wilkinson, E. Bapteste, and J. O. McInerney (2014)
Mol. Biol. Evol. 31, 501-516
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