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Sci. Signal., 12 October 2010
Vol. 3, Issue 143, p. mr3
[DOI: 10.1126/scisignal.3143mr3]


Signal Transduction in Child Health: Closing the Gap Between Clinical and Basic Research

Li Chan1*, Kerstin Albertsson-Wikland2, Cecilia Camacho-Hübner3, and Ze'ev Hochberg4

1 Centre for Endocrinology, William Harvey Research Institute, St. Bartholomew’s and The Royal London School of Medicine and Dentistry, London EC1M 6BQ, UK.
2 Gothenburg Pediatric Growth Research Center, University of Gothenburg, Institute of Clinical Sciences, Department of Pediatrics, The Queen Silvia Children's Hospital, Gothenburg, Sweden.
3 Pediatric Endocrinology, Women and Child Health, Karolinska Institute, Stockholm, Sweden.
4 Division of Pediatric Endocrinology, Meyer Children's Hospital, Rambam Medical Center, and Rappaport Family Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel.

A report on the third NICHe Conference, "New Inroads to Child Health—Child Health and Signal Transduction," Varberg, Sweden, 21 to 23 May 2010

Abstract: Although some diseases are specific to children, many diseases of adults, including obesity and the metabolic syndrome, often originate in childhood. Thus, understanding the mechanisms of disease onset and progression in children is vital not only for child health, but for adult health as well. The NICHe (New Inroads to Child Health) Conference series focuses on future directions in child health, by bringing together clinical and basic scientists with the aim of sharing knowledge to facilitate the development of new therapeutic approaches. This year’s conference, entitled "Child Health and Signal Transduction," focused on G protein–coupled receptor and receptor tyrosine kinase pathways involved in endocrine signaling, how disruption of these pathways can lead to disease, and how understanding these pathways may guide drug discovery.

* Corresponding author. Centre for Endocrinology, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK. Telephone, +44 (0)20-7882-6244; fax, +44 (0)20-7882-6197; e-mail, l.chan{at}

Citation: L. Chan, K. Albertsson-Wikland, C. Camacho-Hübner, Z. Hochberg, Signal Transduction in Child Health: Closing the Gap Between Clinical and Basic Research. Sci. Signal. 3, mr3 (2010).

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