Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 19 October 2010
Vol. 3, Issue 144, p. pe37
[DOI: 10.1126/scisignal.3144pe37]

PERSPECTIVES

Nuclear Emancipation: A Platelet Tour de Force

Sherry L. Spinelli1, Sanjay B. Maggirwar2, Neil Blumberg1, and Richard P. Phipps1,2,3*

1 Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
2 Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
3 Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Abstract: Mammalian platelets are anucleate cells produced by the polyploid megakaryocyte. Platelets are more than just key players in hemostasis (blood clotting in response to injury); they also have important roles in inflammation, immunity, tumor progression, and thrombosis. Complex systems of homeostasis have been described for platelets, including posttranscriptional and translational mechanisms to regulate platelet function. Platelets contain transcription factors, and these proteins have essential roles in regulating nongenomic processes. A study provides evidence for a previously unknown negative feedback pathway for limiting platelet activation that occurs through the nuclear factor {kappa}B transcription factor family. This pathway is mediated by an adenosine 3',5'-monophosphate–independent protein kinase A activity in response to platelet stimulation. Our appreciation of the role of transcription factors in mammalian platelet biology is nascent but holds great promise for both understanding platelet function and translation into clinical uses.

* Corresponding author: Department of Environmental Medicine, Box 850, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA. Telephone, 585-275-8326; fax, 585-276-0239; e-mail, richard_phipps{at}urmc.rochester.edu

Citation: S. L. Spinelli, S. B. Maggirwar, N. Blumberg, R. P. Phipps, Nuclear Emancipation: A Platelet Tour de Force. Sci. Signal. 3, pe37 (2010).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Role of NF-{kappa}B Pathway on Platelet Activation.
M. Schattner (2013)
Circ. Res. 113, e92
   Full Text »    PDF »
Reply to Schattner.
M. T. Rondina, A. S. Weyrich, and G. A. Zimmerman (2013)
Circ. Res. 113, e93
   Full Text »    PDF »
Platelets as Cellular Effectors of Inflammation in Vascular Diseases.
M. T. Rondina, A. S. Weyrich, and G. A. Zimmerman (2013)
Circ. Res. 112, 1506-1519
   Abstract »    Full Text »    PDF »
A Sticky Story for Signal Transducer and Activator of Transcription 3 in Platelets.
K. Chen, M. T. Rondina, and A. S. Weyrich (2013)
Circulation 127, 421-423
   Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882