Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 9 November 2010
Vol. 3, Issue 147, p. tr5
[DOI: 10.1126/scisignal.3147tr5]


Visualizing Calcium Signaling in Astrocytes

R. Douglas Fields*

National Institute of Child Health and Human Development, National Institutes of Health, Building 35, Room 2A211, MSC3713, Bethesda, MD 20892, USA.

Abstract: Astrocytes are nonneuronal cells in the brain (glia) that do not generate electrical impulses but communicate by chemical signaling. This communication can be observed under a microscope with fluorescent calcium indicators that glow more brightly when the concentration of calcium increases inside the cell. Astrocytes release adenosine 5'-triphosphate and other cell signaling molecules that excite membrane receptors on other astrocytes to cause an increase in intracellular calcium in the recipient cell. Many of the substances released by astrocytes also excite neurons, and astrocytes have on their own cell membrane many of the same neurotransmitter receptors used by neurons to communicate across synapses. This allows astrocytes to respond to neural impulse activity, communicate among other astrocytes, and influence neuronal communication by taking up or releasing neurotransmitters from synapses.

* E-mail, fieldsd{at}

Citation: R. D. Fields, Visualizing Calcium Signaling in Astrocytes. Sci. Signal. 3, tr5 (2010).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882