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Sci. Signal., 16 November 2010
Vol. 3, Issue 148, p. pe43
[DOI: 10.1126/scisignal.3148pe43]

PERSPECTIVES

Frizzled Signaling: G{alpha}o and Rab5 at the Crossroads of the Canonical and PCP Pathways?

David Strutt1 and Jean-Paul Vincent2*

1 Medical Research Council (MRC) Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
2 MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.

Abstract: Endocytosis modulates the activities of members of a family of receptors known as Frizzled (Fz) proteins, which control canonical β-catenin signaling and the planar cell polarity pathway; however, what determines which of the two pathways is activated is unclear. Evidence now suggests that the guanosine triphosphatase Rab5, a key regulator of endocytosis, binds directly to Fz proteins and that subsequent trafficking steps determine the outcome of Fz signaling.

* Corresponding author. E-mail, jvincen{at}nimr.mrc.ac.uk

Citation: D. Strutt, J.-P. Vincent, Frizzled Signaling: G{alpha}o and Rab5 at the Crossroads of the Canonical and PCP Pathways? Sci. Signal. 3, pe43 (2010).

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