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Sci. Signal., 23 November 2010
Vol. 3, Issue 149, p. pc21
[DOI: 10.1126/scisignal.3149pc21]


Science Signaling Podcast: 23 November 2010

Elaine F. Reed1 and Annalisa M. VanHook2

1 UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with Elaine Reed about a Research Article published in the 23 November 2010 issue of Science Signaling. Zhang and colleagues report that human leukocyte antigen I (HLA-I) partners with the integrin β4 subunit to induce migration and proliferation of endothelial cells. Interactions between HLA-I and the integrin β4 subunit may contribute to transplant vasculopathy and so represent a potential target for therapies to limit transplant rejection.

Citation: E. F. Reed, A. M. VanHook, Science Signaling Podcast: 23 November 2010. Sci. Signal. 3, pc21 (2010).

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