Focus Issue: Metabolic Signals

Wei Wong^1*

¹ Associate Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This Focus Issue of Science Signaling complements the Science Special Issue on Metabolism (http://www.sciencemag.org/special/metabolism) by turning attention to the pathways and molecules involved in controlling cellular metabolic processes. Highlights include an unexpected role in triggering apoptosis for the insulin receptor and the related IGF-1 receptor (known for their roles in metabolism and growth), a role for lipids as cellular sensors of glucose metabolism, and a mechanism whereby cells can survive oxidative stress by shifting the activity of the cell’s protein degradation complex.

* Corresponding author. E-mail, wwong{at}aaas.org

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
Cancer
Metabolic Gatekeeper

Wei Wong (29 January 2013)
Sci. Signal. 6 (260), ec27. [DOI: 10.1126/scisignal.2004003]
 |  Abstract »

EDITORS' CHOICE
Cancer
Tumorigenic Role for Cancer Metabolism

John F. Foley (11 December 2012)
Sci. Signal. 5 (254), ec323. [DOI: 10.1126/scisignal.2003860]
 |  Abstract »

EDITORS' CHOICE
Pharmacology
An Aspirin a Day?

L. Bryan Ray (22 May 2012)
Sci. Signal. 5 (225), ec145. [DOI: 10.1126/scisignal.2003239]
 |  Abstract »

EDITORS' CHOICE
Metabolism
How Sweet It Is

Wei Wong (28 February 2012)
Sci. Signal. 5 (213), ec64. [DOI: 10.1126/scisignal.2002999]
 |  Abstract »

EDITORS' CHOICE
Physiology
Preserving a Pump with Insulin

Elizabeth M. Adler (24 January 2012)
Sci. Signal. 5 (208), ec27. [DOI: 10.1126/scisignal.2002880]
 |  Abstract »

EDITORS' CHOICE
Cancer
Promoting Proliferation with Nuclear Pyruvate Kinase M2

Nancy R. Gough (6 December 2011)
Sci. Signal. 4 (202), ec337. [DOI: 10.1126/scisignal.4202ec337]
 |  Abstract »

EDITORS' CHOICE
Cancer
Cancer Cell Vulnerability

L. Bryan Ray (6 December 2011)
Sci. Signal. 4 (202), ec338. [DOI: 10.1126/scisignal.4202ec338]
 |  Abstract »

EDITORS' CHOICE
Membranes
A Raft to Insulin Resistance?

Elizabeth M. Adler (11 October 2011)
Sci. Signal. 4 (194), ec283. [DOI: 10.1126/scisignal.4194ec283]
 |  Abstract »

EDITORS' CHOICE
Cell Biology
ERK to Conserve Resources

Annalisa M. VanHook (27 September 2011)
Sci. Signal. 4 (192), ec271. [DOI: 10.1126/scisignal.4192ec271]
 |  Abstract »

EDITORS' CHOICE
Insulin Signaling
Targeting Receptor Stability

John F. Foley (5 July 2011)
Sci. Signal. 4 (180), ec186. [DOI: 10.1126/scisignal.4180ec186]
 |  Abstract »

EDITORS' CHOICE
Structural Biology
Just the Right Amount (of Activation)

Nancy R. Gough (19 April 2011)
Sci. Signal. 4 (169), ec108. [DOI: 10.1126/scisignal.4169ec108]
 |  Abstract »

EDITORS' CHOICE
Metabolism
FGF19 and Liver Metabolism

L. Bryan Ray (29 March 2011)
Sci. Signal. 4 (166), ec93. [DOI: 10.1126/scisignal.4166ec93]
 |  Abstract »

RESEARCH ARTICLES
Metabolism
Wnt Signaling Regulates Hepatic Metabolism

Hongjun Liu, Maria M. Fergusson, J. Julie Wu, Ilsa I. Rovira, Jie Liu, Oksana Gavrilova, Teng Lu, Jianjun Bao, Donghe Han, Michael N. Sack, and Toren Finkel (1 February 2011)
Sci. Signal. 4 (158), ra6. [DOI: 10.1126/scisignal.2001249]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Metabolism
Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch

Yoshikazu Hara, Shu Wakino, Yoshiyuki Tanabe, Maki Saito, Hirobumi Tokuyama, Naoki Washida, Satoru Tatematsu, Kyoko Yoshioka, Koichiro Homma, Kazuhiro Hasegawa, Hitoshi Minakuchi, Keiko Fujimura, Koji Hosoya, Koichi Hayashi, Koichi Nakayama, and Hiroshi Itoh (25 January 2011)
Sci. Signal. 4 (157), ra3. [DOI: 10.1126/scisignal.2001227]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORS' CHOICE
Metabolism
Immune Protection from Metabolic Syndrome?

Nancy R. Gough (4 January 2011)
Sci. Signal. 4 (154), ec8. [DOI: 10.1126/scisignal.4154ec8]
 |  Abstract »

EDITORIAL GUIDES
Cell Biology
2010: Signaling Breakthroughs of the Year

Elizabeth M. Adler (4 January 2011)
Sci. Signal. 4 (154), eg1. [DOI: 10.1126/scisignal.2001770]
 |  Abstract »  |  Full Text »  |  PDF »

In Science Magazine

INTRODUCTION TO SPECIAL ISSUE
Introduction
Metabolism Is Not Boring

L. Bryan Ray (3 December 2010)
Science 330 (6009), 1337. [DOI: 10.1126/science.330.6009.1337]
 |  Full Text »  |  PDF »