Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 7 December 2010
Vol. 3, Issue 151, p. pe47
Dependence Receptors: The Trophic Theory Revisited
Apoptose, Cancer et Développement, CNRS UMR5538, Centre Léon Bérard, University of Lyon, Lyon, France.
Most transmembrane receptors are believed to be inactive in the absence of their cognate ligand and initiate downstream signal transduction only upon ligand binding. However, research has shown that some receptors are also active in the absence of their ligand and induce a "negative" signal to trigger apoptosis. Thus, these receptors, dubbed dependence receptors, create a cellular state of dependence on ligand availability. The dependence receptor theory postulates key roles for these receptors during embryonic development, neurodegenerative diseases, or cancer progression and metastasis and is bolstered by new evidence.
Low Doses of Bovine Somatotropin Enhance Conceptus Development and Fertility in Lactating Dairy Cows.
E. S. Ribeiro, R. G. S. Bruno, A. M. Farias, J. A. Hernandez-Rivera, G. C. Gomes, R. Surjus, L. F. V. Becker, A. Birt, T. L. Ott, J. R. Branen, et al. (2014)
|Abstract »|Full Text »|PDF »
Mitochondrial Control of Cellular Life, Stress, and Death.