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Sci. Signal., 21 December 2010
Vol. 3, Issue 153, p. pe50
[DOI: 10.1126/scisignal.3153pe50]

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T Cell Receptor Signaling Kinetics Takes the Stage

Yuri Sykulev*

Department of Microbiology and Immunology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract: It has been long surmised that the strength of stimulation of the T cell receptor (TCR) determines the robustness of TCR-mediated signaling and the magnitude of a T cell response. However, it is becoming evident that the signal from the TCR develops over time to approach its steady-state, affinity-determined maximal extent and that variations in this time have a substantial effect on the responsiveness of T cells. Here, I discuss data that show that the kinetics of signal propagation in various segments of the TCR signaling network can influence the spatiotemporal regulation of the effector functions of T cells and the quality of the T cell response.

* E-mail, ysykulev{at}lac.jci.tju.edu

Citation: Y. Sykulev, T Cell Receptor Signaling Kinetics Takes the Stage. Sci. Signal. 3, pe50 (2010).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
TNFR-Associated Factor 6 Regulates TCR Signaling via Interaction with and Modification of LAT Adapter.
J.-J. Xie, J.-Q. Liang, L.-H. Diao, A. Altman, and Y. Li (2013)
J. Immunol. 190, 4027-4036
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