Science Signaling Podcast: 4 January 2011

Michael B. Yaffe^1,2 and Annalisa M. VanHook³

¹ Chief Scientific Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
² Koch Institute for Integrative Cancer Research, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³ Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with Science Signaling’s Chief Scientific Editor Michael Yaffe about research published in the journal in 2010. Yaffe reviews some of the most notable Research Articles published in the past year and offers a look ahead to 2011.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH ARTICLES
Cancer
Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

Qi-Wen Fan, Christine Cheng, Chris Hackett, Morri Feldman, Benjamin T. Houseman, Theodore Nicolaides, Daphne Haas-Kogan, C. David James, Scott A. Oakes, Jayanta Debnath, Kevan M. Shokat, and William A. Weiss (9 November 2010)
Sci. Signal. 3 (147), ra81. [DOI: 10.1126/scisignal.2001017]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cancer Biology
Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies

Igor Astsaturov, Vladimir Ratushny, Anna Sukhanova, Margret B. Einarson, Tetyana Bagnyukova, Yan Zhou, Karthik Devarajan, Joshua S. Silverman, Nadezhda Tikhmyanova, Natalya Skobeleva, Anna Pecherskaya, Rochelle E. Nasto, Catherine Sharma, Sandra A. Jablonski, Ilya G. Serebriiskii, Louis M. Weiner, and Erica A. Golemis (21 September 2010)
Sci. Signal. 3 (140), ra67. [DOI: 10.1126/scisignal.2001083]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Immunology
TPL-2–Mediated Activation of MAPK Downstream of TLR4 Signaling Is Coupled to Arginine Availability

Virginie Mieulet, Lijun Yan, Caroline Choisy, Katherine Sully, Julia Procter, Andreas Kouroumalis, Steve Krywawych, Mario Pende, Steven C. Ley, Christophe Moinard, and Richard F. Lamb (17 August 2010)
Sci. Signal. 3 (135), ra61. [DOI: 10.1126/scisignal.2000934]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Immunology
Arginine Usage in Mycobacteria-Infected Macrophages Depends on Autocrine-Paracrine Cytokine Signaling

Joseph E. Qualls, Geoffrey Neale, Amber M. Smith, Mi-Sun Koo, Ashley A. DeFreitas, Huiyuan Zhang, Gilla Kaplan, Stephanie S. Watowich, and Peter J. Murray (17 August 2010)
Sci. Signal. 3 (135), ra62. [DOI: 10.1126/scisignal.2000955]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Immunology
The PI3K Isoforms p110 and p110 Are Essential for Pre–B Cell Receptor Signaling and B Cell Development

Faruk Ramadani, Daniel J. Bolland, Fabien Garcon, Juliet L. Emery, Bart Vanhaesebroeck, Anne E. Corcoran, and Klaus Okkenhaug (10 August 2010)
Sci. Signal. 3 (134), ra60. [DOI: 10.1126/scisignal.2001104]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cancer
HCMV-Encoded Chemokine Receptor US28 Mediates Proliferative Signaling Through the IL-6–STAT3 Axis

Erik Slinger, David Maussang, Andreas Schreiber, Marco Siderius, Afsar Rahbar, Alberto Fraile-Ramos, Sergio A. Lira, Cecilia Söderberg-Nauclér, and Martine J. Smit (3 August 2010)
Sci. Signal. 3 (133), ra58. [DOI: 10.1126/scisignal.2001180]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Immunology
The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling

Jaeyul Kwon, Kristen E. Shatynski, Haiyan Chen, Stanislas Morand, Xavier de Deken, Françoise Miot, Thomas L. Leto, and Mark S. Williams (3 August 2010)
Sci. Signal. 3 (133), ra59. [DOI: 10.1126/scisignal.2000976]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cell Migration
Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

Moritz Kronlage, Jian Song, Lydia Sorokin, Katrin Isfort, Tanja Schwerdtle, Jens Leipziger, Bernard Robaye, Pamela B. Conley, Hee-Cheol Kim, Sarah Sargin, Peter Schön, Albrecht Schwab, and Peter J. Hanley (27 July 2010)
Sci. Signal. 3 (132), ra55. [DOI: 10.1126/scisignal.2000588]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Network Analysis
Signaling to Transcription Networks in the Neuronal Retrograde Injury Response

Izhak Michaelevski, Yael Segal-Ruder, Meir Rozenbaum, Katalin F. Medzihradszky, Ophir Shalem, Giovanni Coppola, Shirley Horn-Saban, Keren Ben-Yaakov, Shachar Y. Dagan, Ida Rishal, Daniel H. Geschwind, Yitzhak Pilpel, Alma L. Burlingame, and Mike Fainzilber (13 July 2010)
Sci. Signal. 3 (130), ra53. [DOI: 10.1126/scisignal.2000952]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Immunology
Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation

Yu Chen, Yongli Yao, Yuka Sumi, Andrew Li, Uyen Kim To, Abdallah Elkhal, Yoshiaki Inoue, Tobias Woehrle, Qin Zhang, Carl Hauser, and Wolfgang G. Junger (8 June 2010)
Sci. Signal. 3 (125), ra45. [DOI: 10.1126/scisignal.2000549]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cancer Biology
EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors

Roi Avraham, Aldema Sas-Chen, Ohad Manor, Israel Steinfeld, Reut Shalgi, Gabi Tarcic, Noa Bossel, Amit Zeisel, Ido Amit, Yaara Zwang, Espen Enerly, Hege G. Russnes, Francesca Biagioni, Marcella Mottolese, Sabrina Strano, Giovanni Blandino, Anne-Lise Børresen-Dale, Yitzhak Pilpel, Zohar Yakhini, Eran Segal, and Yosef Yarden (1 June 2010)
Sci. Signal. 3 (124), ra43. [DOI: 10.1126/scisignal.2000876]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Development
The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development

Takamitsu Maruyama, Anthony J. Mirando, Chu-Xia Deng, and Wei Hsu (25 May 2010)
Sci. Signal. 3 (123), ra40. [DOI: 10.1126/scisignal.2000727]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cell Biology
In Vivo Identification of Regulators of Cell Invasion Across Basement Membranes

David Q. Matus, Xiao-Yan Li, Sarah Durbin, Daniel Agarwal, Qiuyi Chi, Stephen J. Weiss, and David R. Sherwood (4 May 2010)
Sci. Signal. 3 (120), ra35. [DOI: 10.1126/scisignal.2000654]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cell Biology
Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

Christina H. Eng, Ker Yu, Judy Lucas, Eileen White, and Robert T. Abraham (27 April 2010)
Sci. Signal. 3 (119), ra31. [DOI: 10.1126/scisignal.2000911]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cancer
Identification of the miR-106b~25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

Laura Poliseno, Leonardo Salmena, Luisa Riccardi, Alessandro Fornari, Min Sup Song, Robin M. Hobbs, Paolo Sportoletti, Shorheh Varmeh, Ainara Egia, Giuseppe Fedele, Lucia Rameh, Massimo Loda, and Pier Paolo Pandolfi (13 April 2010)
Sci. Signal. 3 (117), ra29. [DOI: 10.1126/scisignal.2000594]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Neuroscience
Polycomb Group Proteins as Epigenetic Mediators of Neuroprotection in Ischemic Tolerance

Martha Stapels, Chelsea Piper, Tao Yang, Minghua Li, Cheri Stowell, Zhi-gang Xiong, Julie Saugstad, Roger P. Simon, Scott Geromanos, James Langridge, Jing-quan Lan, and An Zhou (2 March 2010)
Sci. Signal. 3 (111), ra15. [DOI: 10.1126/scisignal.2000502]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Structural Biology
Crystal Structure of the -Kinase Domain of Dictyostelium Myosin Heavy Chain Kinase A

Qilu Ye, Scott W. Crawley, Yidai Yang, Graham P. Côté, and Zongchao Jia (2 March 2010)
Sci. Signal. 3 (111), ra17. [DOI: 10.1126/scisignal.2000525]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Biochemistry
Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis

Zihao Wang, Namrata D. Udeshi, Chad Slawson, Philip D. Compton, Kaoru Sakabe, Win D. Cheung, Jeffrey Shabanowitz, Donald F. Hunt, and Gerald W. Hart (12 January 2010)
Sci. Signal. 3 (104), ra2. [DOI: 10.1126/scisignal.2000526]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cell Cycle
Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

Jesper V. Olsen, Michiel Vermeulen, Anna Santamaria, Chanchal Kumar, Martin L. Miller, Lars J. Jensen, Florian Gnad, Jürgen Cox, Thomas S. Jensen, Erich A. Nigg, Søren Brunak, and Matthias Mann (12 January 2010)
Sci. Signal. 3 (104), ra3. [DOI: 10.1126/scisignal.2000475]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PODCASTS
Cell Biology
Science Signaling Podcast: 5 January 2010

Michael B. Yaffe and Annalisa M. VanHook (5 January 2010)
Sci. Signal. 3 (103), pc1. [DOI: 10.1126/scisignal.3103pc1]
 |  Abstract »  |  Full Text »  |  Podcast »