Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 11 January 2011
Vol. 4, Issue 155, p. pe1
[DOI: 10.1126/scisignal.2001672]


Autonomic Modulation of Olfactory Signaling

Randy A. Hall*

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract: The olfactory epithelium is extensively innervated by sympathetic nerve endings, which release norepinephrine, and parasympathetic nerve endings, which release acetylcholine. Because olfactory sensory neurons have adrenergic and muscarinic receptors in addition to odorant receptors, autonomic stimulation can modulate the responses of olfactory sensory neurons to odorants. Recent studies have shed light on the molecular mechanisms that underlie crosstalk between muscarinic and odorant receptor signaling. The emerging view is that the stimulation of odorant receptor signaling by odorants, which is the earliest step in olfaction, can be substantially regulated by the autonomic nervous system.

* E-mail, rhall{at}

Citation: R. A. Hall, Autonomic Modulation of Olfactory Signaling. Sci. Signal. 4, pe1 (2011).

Read the Full Text

Acetylcholine enhances excitability by lowering the threshold of spike generation in olfactory receptor cells.
M. Ohkuma, F. Kawai, and E.-i. Miyachi (2013)
J Neurophysiol 110, 2082-2089
   Abstract »    Full Text »    PDF »
Human proprioceptive adaptations during states of height-induced fear and anxiety.
J. R. Davis, B. C. Horslen, K. Nishikawa, K. Fukushima, R. Chua, J. T. Inglis, and M. G. Carpenter (2011)
J Neurophysiol 106, 3082-3090
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882