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Sci. Signal., 22 February 2011
Vol. 4, Issue 161, p. mr3
[DOI: 10.1126/scisignal.2001687]

MEETING REPORTS

Receptors, Signaling Networks, and Disease

Natalia Cuesta1*, Noa B. Martín-Cófreces2,3, Cristina Murga3,4, and Hisse M. van Santen1

All authors contributed equally to this work.
1 Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 28049 Madrid, Spain.
2 Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Fundación pro-CNIC, 28029 Madrid, Spain.
3 Instituto de Investigación Sanitaria Princesa (IP), Hospital La Princesa, 28006 Madrid, Spain.
4 Department of Molecular Biology, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 28049 Madrid, Spain.

A report on the INSINET symposium held in Madrid, Spain, 23 to 24 September 2010.

Abstract: Over the past years, a holistic approach has been applied to the study of the field of receptor signaling, permitting the analysis of how the interaction between receptors and their cellular environment determines receptor function and the study of the role of these receptors, under both normal and pathophysiological conditions, in whole organisms. This has been facilitated by the development of high-resolution microscopy techniques, which allow single-molecule or spatiotemporal resolution, or both, of signaling processes at the cellular and organismal levels. Concurrently, the role of these signaling pathways can be tested in increasingly sophisticated murine disease models. Finally, computational approaches aid in predicting and understanding receptor behavior. The program of the Madrid meeting reflected this integrated approach, highlighting signaling by and dynamics and regulation of immune cell receptors, the T cell receptor and B cell receptor, and signaling by and regulation of G protein–coupled receptors.

* Corresponding author: Telephone, +34 (91) 196-4572; fax, +34 (91) 196-4420; e-mail, ncuesta{at}cbm.uam.es

Citation: N. Cuesta, N. B. Martín-Cófreces, C. Murga, H. M. van Santen, Receptors, Signaling Networks, and Disease. Sci. Signal. 4, mr3 (2011).

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