Sci. Signal., 22 February 2011
Science Signaling Podcast: 22 February 2011
Alexander Hoffmann1, 2, 3 and Annalisa M. VanHook4
1 Signaling Systems Laboratory, University of California–San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Abstract: This is a conversation with Alexander Hoffmann about a Research Article published in the 22 February 2011 issue of Science Signaling. Hoffmann discusses his groups report on how homodimers of the nuclear factor B (NF-B) p50 regulate the innate immune response. The study revealed that NF-B homodimers compete with interferon regulatory factors (IRFs) for binding to guanine-rich interferon response elements (G-IREs) to restrict the activation of antiviral genes to only the appropriate stimuli.
Citation: A. Hoffmann, A. M. VanHook, Science Signaling Podcast: 22 February 2011. Sci. Signal. 4, pc3 (2011).
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