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Sci. Signal., 22 February 2011
Vol. 4, Issue 161, p. pc3
[DOI: 10.1126/scisignal.2001898]

PODCASTS

Science Signaling Podcast: 22 February 2011

Alexander Hoffmann1, 2, 3 and Annalisa M. VanHook4

1 Signaling Systems Laboratory, University of California–San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
2 Department of Chemistry and Biochemistry, University of California–San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
3 San Diego Center for Systems Biology, University of California–San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
4 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with Alexander Hoffmann about a Research Article published in the 22 February 2011 issue of Science Signaling. Hoffmann discusses his group’s report on how homodimers of the nuclear factor {kappa}B (NF-{kappa}B) p50 regulate the innate immune response. The study revealed that NF-{kappa}B homodimers compete with interferon regulatory factors (IRFs) for binding to guanine-rich interferon response elements (G-IREs) to restrict the activation of antiviral genes to only the appropriate stimuli.

Citation: A. Hoffmann, A. M. VanHook, Science Signaling Podcast: 22 February 2011. Sci. Signal. 4, pc3 (2011).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882