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Sci. Signal., 15 March 2011
Vol. 4, Issue 164, p. pe13
[DOI: 10.1126/scisignal.2001875]

PERSPECTIVES

Inducible Gene Expression in Mammals: Plants Add to the Menu

Sean R. Cutler*

Center for Plant Cell Biology, Department of Botany and Plant Sciences, Department of Chemistry, University of California Riverside, Riverside, CA 92507, USA.

Abstract: Achieving inducible gene expression in mammalian cells with inexpensive and nontoxic inducers is an ongoing quest. The plant hormone abscisic acid has now been added to the list of compounds that can be used for regulating transcription and controlling protein function by induced proximity. These advances may enable new clinical applications of proximity-induced systems, and they highlight the value of fundamental research in plant biology.

* E-mail, sean.cutler{at}ucr.edu

Citation: S. R. Cutler, Inducible Gene Expression in Mammals: Plants Add to the Menu. Sci. Signal. 4, pe13 (2011).

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