Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 22 March 2011
Vol. 4, Issue 165, p. mr4
[DOI: 10.1126/scisignal.2001709]


The Yin and Yang of Signaling in Tregs and TH17 Cells

Fan Pan1, Huimin Fan2, Ling Lu3*, Zhongmin Liu2*, and Shuiping Jiang2*

1 Immunology and Hematopoiesis Division, Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
2 Shanghai East Hospital of Tongji University, Shanghai 200120, China.
3 Department of Liver Transplantation, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

A report on the Second International Conference on Regulatory T Cells and TH17 Cells and Clinical Application in Human Diseases: "China Tregs/Th17 2010 Shanghai Conference," Shanghai, China, 17 to 20 July 2010.

Abstract: Substantial advances in our understanding of the developmental and functional relationship between regulatory T cells (Tregs) and T helper 17 (TH17) cells and their potential clinical applications have been made. In response to these breakthroughs, the second international conference entitled "China Tregs/Th17 2010 Shanghai Conference," held in Shanghai, China, was dedicated to this topic. Various types of Tregs and TH17 cells, as well as their relevant cytokines, were discussed. Here, we summarize some of the findings shared at the conference, specifically focusing on the biology of TH17 cells, including interleukin-17 (IL-17)–producing innate cells, Tregs, and the factors that control the critical balance between Tregs and cells of the TH17 lineage.

* Corresponding authors. E-mail, shuiping.jiang{at} (S.J.); zhongmin_liu{at} (Z.L.); lvling{at} (L.L.)

Citation: F. Pan, H. Fan, L. Lu, Z. Liu, S. Jiang, The Yin and Yang of Signaling in Tregs and TH17 Cells. Sci. Signal. 4, mr4 (2011).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882