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Sci. Signal., 29 March 2011
Vol. 4, Issue 166, p. pc6
[DOI: 10.1126/scisignal.2001941]

PODCASTS

Science Signaling Podcast: 29 March 2011

Thomas G. Graeber1,2 and Annalisa M. VanHook3

1 Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center; David Geffen School of Medicine, Department of Molecular and Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
2 California NanoSystems Institute, University of California, Los Angeles CA 90095, USA.
3 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This Podcast features a conversation with the senior author of a Research Article published in the March 29 issue of Science Signaling. Thomas Graeber discusses his group’s phosphoproteomic analysis of a leukemia cell line, which reveals a mechanism by which leukemia cells may become resistant to chemotherapeutic agents that target tyrosine kinases. They found that the sensitivity of leukemias driven by the Bcr-Abl fusion protein to tyrosine kinase inhibitors depends on the cells’ reliance on negative feedback mechanisms that limit the activity of the Src family of tyrosine kinases.

Citation: T. G. Graeber, A. M. VanHook, Science Signaling Podcast: 29 March 2011. Sci. Signal. 4, pc6 (2011).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882