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Sci. Signal., 3 May 2011
Vol. 4, Issue 171, p. pe24
New Roles for Lysosomal Trafficking in Morphogen Gradient Sensing
Elena Rainero and
Jim C. Norman*
Integrin Cell Biology Laboratory, Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, Scotland, UK.
The way in which cells recognize their position in a gradient of morphogen controls differentiation during embryogenesis. New findings indicate that the rate at which internalized morphogen receptors are trafficked to lysosomes is key to the accurate and precise sensing of morphogen gradients and the appropriate initiation of differentiation programs during development.