Sci. Signal., 14 June 2011
Science Signaling Podcast: 14 June 2011
Richard Treisman1, Neil Q. McDonald2,3,4, Stéphane Mouilleron2, and Annalisa M. VanHook5
1 Transcription Group, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Abstract: This podcast features a conversation with Richard Treisman, Neil McDonald, and Stéphane Mouilleron, authors of a Research Article published in the 14 June 2011 issue of Science Signaling. The authors discuss how increasing concentrations of monomeric actin trap the transcriptional coactivator MRTF-A, which couples changes in actin concentration to gene expression, in the cytoplasm, thus preventing it from activating expression of target genes. The crystal structure of actin bound to MRTF-A reveals an unusual mode of actin binding to a target protein.
Citation: R. Treisman, N. Q. McDonald, S. Mouilleron, A. M. VanHook, Science Signaling Podcast: 14 June 2011. Sci. Signal. 4, pc11 (2011).
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