Science Signaling Podcast: 28 June 2011

Silke Hauf¹, Mark Winey², Michele H. Jones², Jamie M. Keck², and Annalisa M. VanHook³

¹ Friedrich Miescher Laboratory of the Max Planck Society, 72076 Tuebingen, Germany.
² Department of Molecular, Cellular, and Developmental Biology, UCB 347, University of Colorado, Boulder, CO 80309, USA.
³ Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features conversations with authors of studies on cell cycle–dependent protein phosphorylation that appear in the 28 June 2011 issue of Science Signaling and the 24 June 2011 issue of Science. The senior author of the Science Signaling Research Article by Koch et al. describes her group’s identification of substrates of the kinase Aurora, which is required for mitosis throughout eukaryotes, and the implications of these findings in light of the recent development of Aurora inhibitors for treating cancer. Authors of a Research Report by Keck et al. that appears in Science discuss their phosphoproteomic analysis of centrosomal proteins that are phosphorylated during mitosis. Given the conserved nature of many of the proteins that control mitosis, both studies have important implications for understanding the dynamics of protein phosphorylation, and therefore regulation, during the cell cycle.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
Phosphoproteomics
Sorting Out the Centrosome

L. Bryan Ray (28 June 2011)
Sci. Signal. 4 (179), ec179. [DOI: 10.1126/scisignal.4179ec179]
 |  Abstract »

EDITORIAL GUIDES
Mitosis
Focus Issue: Choreographing the Dance of the Mitotic Kinases

Nancy R. Gough (28 June 2011)
Sci. Signal. 4 (179), eg5. [DOI: 10.1126/scisignal.2002280]
 |  Abstract »  |  Full Text »  |  PDF »

PERSPECTIVES
Biochemistry
Substrates of Mitotic Kinases

Louise N. Johnson (28 June 2011)
Sci. Signal. 4 (179), pe31. [DOI: 10.1126/scisignal.2002234]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH RESOURCES
Phosphoproteomics
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

Arminja N. Kettenbach, Devin K. Schweppe, Brendan K. Faherty, Dov Pechenick, Alexandre A. Pletnev, and Scott A. Gerber (28 June 2011)
Sci. Signal. 4 (179), rs5. [DOI: 10.1126/scisignal.2001497]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH RESOURCES
Phosphoproteomics
Mitotic Substrates of the Kinase Aurora with Roles in Chromatin Regulation Identified Through Quantitative Phosphoproteomics of Fission Yeast

André Koch, Karsten Krug, Stuart Pengelley, Boris Macek, and Silke Hauf (28 June 2011)
Sci. Signal. 4 (179), rs6. [DOI: 10.1126/scisignal.2001588]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

In Science Magazine

REPORTS
A Cell Cycle Phosphoproteome of the Yeast Centrosome

Jamie M. Keck, Michele H. Jones, Catherine C. L. Wong, Jonathan Binkley, Daici Chen, Sue L. Jaspersen, Eric P. Holinger, Tao Xu, Mario Niepel, Michael P. Rout, Jackie Vogel, Arend Sidow, John R. Yates, III, and Mark Winey (24 June 2011)
Science 332 (6037), 1557. [DOI: 10.1126/science.1205193]
 |  Abstract »  |  Full Text »  |  PDF »  |  Supporting Online Material »