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Sci. Signal., 28 June 2011
Vol. 4, Issue 179, p. pe31
Substrates of Mitotic Kinases
Louise N. Johnson*
Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Most signaling pathways in cells involve numerous phosphorylation reactions. Some of the rules for kinase-substrate specificity are known, but a complete description of all substrates is missing. Research published in Science Signaling addresses the process of mitosis and asks how the relevant kinases recognize substrate sequence motifs and, in the cellular context, what substrates are phosphorylated and where. The results increase our molecular understanding of how individual events are coordinated during the process of cell division and show the importance of both sequence epitopes for kinase specificity and the notion of a sense of place through localization in subcellular compartments.
Silke Hauf, Mark Winey, Michele H. Jones, Jamie M. Keck, and Annalisa M. VanHook (28 June 2011) Sci. Signal.4 (179), pc12.
[DOI: 10.1126/scisignal.2002245] |Abstract »|Full Text »|Podcast »
Jes Alexander, Daniel Lim, Brian A. Joughin, Björn Hegemann, James R. A. Hutchins, Tobias Ehrenberger, Frank Ivins, Fabio Sessa, Otto Hudecz, Erich A. Nigg, Andrew M. Fry, Andrea Musacchio, P. Todd Stukenberg, Karl Mechtler, Jan-Michael Peters, Stephen J. Smerdon, and Michael B. Yaffe (28 June 2011) Sci. Signal.4 (179), ra42.
[DOI: 10.1126/scisignal.2001796] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »