Substrates of Mitotic Kinases

Louise N. Johnson^*

Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.

Abstract: Most signaling pathways in cells involve numerous phosphorylation reactions. Some of the rules for kinase-substrate specificity are known, but a complete description of all substrates is missing. Research published in Science Signaling addresses the process of mitosis and asks how the relevant kinases recognize substrate sequence motifs and, in the cellular context, what substrates are phosphorylated and where. The results increase our molecular understanding of how individual events are coordinated during the process of cell division and show the importance of both sequence epitopes for kinase specificity and the notion of a sense of place through localization in subcellular compartments.

* Corresponding author. E-mail, louise.johnson{at}bioch.ox.ac.uk

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORIAL GUIDES
Mitosis
Focus Issue: Choreographing the Dance of the Mitotic Kinases

Nancy R. Gough (28 June 2011)
Sci. Signal. 4 (179), eg5. [DOI: 10.1126/scisignal.2002280]
 |  Abstract »  |  Full Text »  |  PDF »

PODCASTS
Phosphoproteomics
Science Signaling Podcast: 28 June 2011

Silke Hauf, Mark Winey, Michele H. Jones, Jamie M. Keck, and Annalisa M. VanHook (28 June 2011)
Sci. Signal. 4 (179), pc12. [DOI: 10.1126/scisignal.2002245]
 |  Abstract »  |  Full Text »  |  Podcast »

RESEARCH ARTICLES
Mitotic Kinases
Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

Jes Alexander, Daniel Lim, Brian A. Joughin, Björn Hegemann, James R. A. Hutchins, Tobias Ehrenberger, Frank Ivins, Fabio Sessa, Otto Hudecz, Erich A. Nigg, Andrew M. Fry, Andrea Musacchio, P. Todd Stukenberg, Karl Mechtler, Jan-Michael Peters, Stephen J. Smerdon, and Michael B. Yaffe (28 June 2011)
Sci. Signal. 4 (179), ra42. [DOI: 10.1126/scisignal.2001796]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH RESOURCES
Phosphoproteomics
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

Arminja N. Kettenbach, Devin K. Schweppe, Brendan K. Faherty, Dov Pechenick, Alexandre A. Pletnev, and Scott A. Gerber (28 June 2011)
Sci. Signal. 4 (179), rs5. [DOI: 10.1126/scisignal.2001497]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH RESOURCES
Phosphoproteomics
Mitotic Substrates of the Kinase Aurora with Roles in Chromatin Regulation Identified Through Quantitative Phosphoproteomics of Fission Yeast

André Koch, Karsten Krug, Stuart Pengelley, Boris Macek, and Silke Hauf (28 June 2011)
Sci. Signal. 4 (179), rs6. [DOI: 10.1126/scisignal.2001588]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »