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Sci. Signal., 9 August 2011
Vol. 4, Issue 185, p. pc15
[DOI: 10.1126/scisignal.2002367]


Science Signaling Podcast: 9 August 2011

Mark von Zastrow1 and Annalisa M. VanHook2

1 Department of Psychiatry and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features a conversation with the senior author of a Research Article published in the 9 August 2011 issue of Science Signaling. Lau et al. examined how signaling through µ-type opioid receptors (MORs) differs between receptor activation by the endogenous opioid peptide enkephalin and activation by the partial agonist morphine. The authors found that these ligands induced differential phosphorylation of the MOR C-terminal tail, which, in turn, differentially regulated receptor endocytosis and therefore activity.

Citation: M. von Zastrow, A. M. VanHook, Science Signaling Podcast: 9 August 2011. Sci. Signal. 4, pc15 (2011).

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