Focus Issue: Series on Computational and Systems Biology

Nancy R. Gough^*

Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: The application of computational biology and systems biology is yielding quantitative insight into cellular regulatory phenomena. For the month of September, Science Signaling highlights research featuring computational approaches to understanding cell signaling and investigation of signaling networks, a series of Teaching Resources from a course in systems biology, and various other articles and resources relevant to the application of computational biology and systems biology to the study of signal transduction.

* Corresponding author. E-mail, ngough{at}aaas.org

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH RESOURCES
Systems Biology
Protein Complex–Based Analysis Framework for High-Throughput Data Sets

Arunachalam Vinayagam, Yanhui Hu, Meghana Kulkarni, Charles Roesel, Richelle Sopko, Stephanie E. Mohr, and Norbert Perrimon (26 February 2013)
Sci. Signal. 6 (264), rs5. [DOI: 10.1126/scisignal.2003629]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORIAL GUIDES
Computational Biology
Focus Issue: Adding Math to the Signaling Toolkit

Wei Wong and John F. Foley (17 April 2012)
Sci. Signal. 5 (220), eg5. [DOI: 10.1126/scisignal.2003112]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Computational Biology
Load-Induced Modulation of Signal Transduction Networks

Peng Jiang, Alejandra C. Ventura, Eduardo D. Sontag, Sofia D. Merajver, Alexander J. Ninfa, and Domitilla Del Vecchio (11 October 2011)
Sci. Signal. 4 (194), ra67. [DOI: 10.1126/scisignal.2002152]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Stress Signaling
Time-Dependent Quantitative Multicomponent Control of the G₁-S Network by the Stress-Activated Protein Kinase Hog1 upon Osmostress

Miquel Àngel Adrover, Zhike Zi, Alba Duch, Jörg Schaber, Alberto González-Novo, Javier Jimenez, Mariona Nadal-Ribelles, Josep Clotet, Edda Klipp, and Francesc Posas (27 September 2011)
Sci. Signal. 4 (192), ra63. [DOI: 10.1126/scisignal.2002204]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

TEACHING RESOURCES
Computational Biology
Systems Biology—Biomedical Modeling

Eric A. Sobie, Young-Seon Lee, Sherry L. Jenkins, and Ravi Iyengar (13 September 2011)
Sci. Signal. 4 (190), tr2. [DOI: 10.1126/scisignal.2001989]
 |  Abstract »  |  Full Text »  |  PDF »