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Sci. Signal., 1 November 2011
Vol. 4, Issue 197, p. pc23
[DOI: 10.1126/scisignal.2002614]


Science Signaling Podcast: 1 November 2011

Xiaoxia Li1 and Annalisa M. VanHook2

1 Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features a conversation with the senior author of a Research Article published in the 1 November 2011 issue of Science Signaling. Xiaoxia Li discusses her group’s identification of a region within the adaptor protein Act1 that is critical for its binding to the proinflammatory Interleukin-17 receptor. They designed a cell-permeable peptide that can bind to the receptor and inhibit its signaling, thus reducing inflammation, in a mouse model. Similar strategies might be successful in developing methods for blocking IL-17-dependent inflammatory disease in humans.

Citation: X. Li, A. M. VanHook, Science Signaling Podcast: 1 November 2011. Sci. Signal. 4, pc23 (2011).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882