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Sci. Signal., 29 November 2011
Vol. 4, Issue 201, p. pe45
[DOI: 10.1126/scisignal.2002670]


Making Muscles Grow by G Protein–Coupled Receptor Signaling

Denis C. Guttridge*

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, 460 West 12th Avenue, BRT 910, Columbus, OH 43210, USA.

Abstract: Activation of G protein–coupled receptors is involved in regulating many cellular responses, but less is known regarding the role of these receptors in the differentiation and maintenance of skeletal muscle. New findings implicate the inhibitor subunit Gαi2 as a vital mediator of myofiber maturation and growth, operating through multiple signaling pathways to selectively stimulate protein synthesis or inhibit cytokine-dependent protein turnover.

* Corresponding author. E-mail, denis.guttridge{at}

Citation: D. C. Guttridge, Making Muscles Grow by G Protein–Coupled Receptor Signaling. Sci. Signal. 4, pe45 (2011).

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