Sci. Signal., 20 December 2011
Science Signaling Podcast: 20 December 2011
Peter H. Krammer1 and Annalisa M. VanHook2
1 Division of Immunogenetics (D030), Tumor Immunology Program, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Abstract: This Podcast features a conversation with the senior author of a Research Article published in the 20 December 2011 issue of Science Signaling. Peter Krammer discusses his groups finding that suppression of conventional T cells by regulatory T cells involves inhibition of calcium signaling downstream of the T cell receptor. Understanding the mechanisms by which regulatory T cells suppress conventional T cells is important because too much suppression can dampen the antitumor response, and too little suppression can lead to autoimmune disease.
Citation: P. H. Krammer, A. M. VanHook, Science Signaling Podcast: 20 December 2011. Sci. Signal. 4, pc26 (2011).
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