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Sci. Signal., 10 January 2012
Vol. 5, Issue 206, p. eg2
[DOI: 10.1126/scisignal.2002806]


Focus Issue: Wnt and β-Catenin Signaling in Development and Disease

Nancy R. Gough*

Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: The Wnt pathways represent key signaling networks involved in development, both in tissue specification and in cellular migration. Wnt signaling also plays key roles in tissue homeostasis in adult animals, and aberrant Wnt signaling is associated with several forms of cancer. This issue includes descriptions of a proapoptotic function for Wnt signaling in melanoma, an interplay between Wnt and bone morphogenetic proteins in tooth organogenesis, and a noncanonical role for Wnt in neuronal guidance.

* Corresponding author. E-mail, ngough{at}

Citation: N. R. Gough, Focus Issue: Wnt and β-Catenin Signaling in Development and Disease. Sci. Signal. 5, eg2 (2012).

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