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Sci. Signal., 31 January 2012
Vol. 5, Issue 209, p. pc2
[DOI: 10.1126/scisignal.2002870]


Science Signaling Podcast: 31 January 2012

Caleb M. Cardon1, Jared Rutter1, and Annalisa M. VanHook2

1 Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005, USA.

Abstract: This Podcast features a conversation with authors of a Research Article published in the 31 January 2012 issue of Science Signaling. Jared Rutter and Caleb Cardon discuss their discovery that signaling through PAS kinases can bypass signaling through Tor2 in yeast. Tor2 is one of two Tor kinases that participate in signaling through the yeast target of rapamycin (TOR) pathway, which integrates information about cellular nutrient and energy status to control growth. Cells lacking Tor2 cannot grow, but activation of either of two PAS kinases can restore growth to Tor2-deficient cells by activating a downstream target of Tor2 signaling. The authors demonstrate that PAS kinases are part of a protein complex that may integrate metabolic and stress signaling.

Citation: C. M. Cardon, J. Rutter, A. M. VanHook, Science Signaling Podcast: 31 January 2012. Sci. Signal. 5, pc2 (2012).

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