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Sci. Signal., 28 February 2012
Vol. 5, Issue 213, p. pe8
[DOI: 10.1126/scisignal.2002897]


Chemoattractant Signaling in Dictyostelium: Adaptation and Amplification

Pablo A. Iglesias*

Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.

Abstract: The social amoebae Dictyostelium discoideum has long proved a powerful model organism for studying how cells sense and interpret chemoattractant gradients. Because of the rich behavior observed in its response to chemoattractants, as well as the complex nature of the signaling pathways involved, this research has attracted and benefited from the use of theoretical models. Recent quantitative experiments provide support for a popular model: the local excitation, global inhibition mechanism of gradient sensing. Here, I discuss these findings and suggest some important open problems.

* Corresponding author. Telephone: +1-410-516-6026; fax: +1-410-516-5566; e-mail: pi{at}

Citation: P. A. Iglesias, Chemoattractant Signaling in Dictyostelium: Adaptation and Amplification. Sci. Signal. 5, pe8 (2012).

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Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture.
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Phil Trans R Soc B 368, 20130117
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