Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Signal., 27 March 2012
Vol. 5, Issue 217, p. eg4
[DOI: 10.1126/scisignal.2003044]


Focus Issue: TOR Signaling, a Tale of Two Complexes

Nancy R. Gough*

Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: Through its association with two distinct protein complexes, target of rapamycin (TOR) complex 1 (TORC1) and TOR complex 2 (TORC2), the kinase TOR coordinates cellular growth with cell cycles, growth factors, and nutrients. The interconnected TOR signaling network participates in various physiological and pathophysiological conditions, such as aging, stem cell renewal, cell specification, and carcinogenesis; therefore, understanding the details of this system may yield new ways to promote longer, healthier living. This issue provides an overview of research on TOR signaling that has emerged since the issue Science Signaling devoted to this topic in 2009.

* Corresponding author. E-mail: ngough{at}

Citation: N. R. Gough, Focus Issue: TOR Signaling, a Tale of Two Complexes. Sci. Signal. 5, eg4 (2012).

Read the Full Text

Increased Mammalian Target of Rapamycin Complex 2 Signaling Promotes Age-Related Decline in CD4 T Cell Signaling and Function.
E. Perkey, D. Fingar, R. A. Miller, and G. G. Garcia (2013)
J. Immunol. 191, 4648-4655
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882