Sci. Signal., 10 April 2012
Science Signaling Podcast: 10 April 2012
Maiken Nedergaard1, Katsuhiko Mikoshiba2,3, and Annalisa M. VanHook4
1 Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical School, Rochester, NY 14640, USA.
Abstract: This Podcast features conversations with the authors of two Research Articles published in the 3 April 2012 issue of Science Signaling. Groups led by Maiken Nedergaard and Katsuhiko Mikoshiba published new findings about how calcium signaling in astocytes modulates synaptic activity. Astrocytes are electrically nonexcitable, nonneuronal cells that can generate calcium waves that regulate synaptic activity and local blood flow. Nedergaards group found that astrocytes modulated synaptic activity by altering local concentrations of extracellular K+. Mikoshibas group reported that calcium signals are generated in the processes of astrocytes independently of the soma (cell body). This compartmentalization of calcium signals suggests that different processes of the same astrocyte may regulate target cells independently of one another and of the soma.
Citation: M. Nedergaard, K. Mikoshiba, A. M. VanHook, Science Signaling Podcast: 10 April 2012. Sci. Signal. 5, pc8 (2012).
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