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Sci. Signal., 29 May 2012
Vol. 5, Issue 226, p. re2
[DOI: 10.1126/scisignal.2003013]

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Signal Activation and Inactivation by the Gα Helical Domain: A Long-Neglected Partner in G Protein Signaling

Henrik G. Dohlman* and Janice C. Jones

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract: Heterotrimeric guanine nucleotide–binding proteins (G proteins) are positioned at the top of many signal transduction pathways. The G protein α subunit is composed of two domains, one that resembles Ras and another that is composed entirely of α helices. Historically most attention has focused on the Ras-like domain, but emerging evidence reveals that the helical domain is an active participant in G protein signaling.

*Corresponding author. E-mail: hdohlman{at}med.unc.edu

Citation: H. G. Dohlman, J. C. Jones, Signal Activation and Inactivation by the Gα Helical Domain: A Long-Neglected Partner in G Protein Signaling. Sci. Signal. 5, re2 (2012).

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