Sci. Signal., 5 June 2012
Immunology So Selective
Kristen L. Mueller
Science, AAAS, Washington, DC 20005, USA
The key elements for long-lived antibody-mediated immunity—memory B cells and plasmablasts—are generated in germinal centers, where B cells expressing high-affinity antigen receptors are selected for survival and proliferation in a process called affinity maturation. Unexpectedly, Khalil et al. (see the Perspective by Bannard and Cyster) found that, in contrast to naïve B cells and B cells outside the germinal center, proximal signaling events are impaired downstream of the antigen receptor in mouse germinal center B cells.
Citation: K. L. Mueller, So Selective. Sci. Signal. 5, ec157 (2012).
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