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Sci. Signal., 31 July 2012
Vol. 5, Issue 235, p. pe33
[DOI: 10.1126/scisignal.2003383]

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Tyrosine Kinases EnAbling Adaptor Molecules for Chemokine-Induced Rap1 Activation in T Cells

Laurent P. Malherbe* and Demin Wang*

Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA.

Abstract: Chemokines regulate T cell trafficking into secondary lymphoid organs and migration across endothelial cells in response to inflammatory signals. The small guanosine triphosphatase Rap1 is a critical regulator of chemokine signaling in T cells, but how chemokines activate Rap1 has been unclear. A study showed that Abl family tyrosine kinases were essential for chemokine-induced Rap1 activation, T cell polarization, and migration. Abl family kinases promoted Rap1 activation by phosphorylating the adaptor protein human enhancer of filamentation 1 (HEF1), thus establishing a critical Abl-HEF1-Rap1 signaling axis for chemokine-induced T cell migration.

* Corresponding author. E-mail: laurent.malherbe{at}bcw.edu (L.P.M.); demin.wang{at}bcw.edu (D.W.)

Citation: L. P. Malherbe, D. Wang, Tyrosine Kinases EnAbling Adaptor Molecules for Chemokine-Induced Rap1 Activation in T Cells. Sci. Signal. 5, pe33 (2012).

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