Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 7 August 2012
Vol. 5, Issue 236, p. re4
[DOI: 10.1126/scisignal.2002886]

REVIEWS

The Abluminal Endothelial Membrane in Neurovascular Remodeling in Health and Disease

Dirk M. Hermann* and Ayman ElAli*

Department of Neurology, University Hospital Essen, Hufelandstrasse 55, D-45122 Essen, Germany.

Abstract: After brain injury, blood-brain barrier (BBB) integrity can be compromised as a consequence of the breakdown of cell-cell interactions in the neurovascular unit, resulting in the loss of the characteristic endothelial luminal-to-abluminal structure. During the process of restoration of the BBB and vascularization, the endothelial cells are continuously reshaped, with both the luminal and abluminal membranes serving as sites of signaling. Here, we focus on the bidirectional signaling processes that are rapidly initiated between endothelial and perivascular cells and occur in certain brain diseases or in response to injury. The goal of these processes is (i) the reemergence of endothelial cell polarity, (ii) the remodeling of extracellular matrix interactions, (iii) the realignment of pericytes and astrocytic endfeet with endothelial cells, and (iv) the restitution of a well-organized and stable BBB. This abluminal membrane exemplifies how the brain vasculature responds to stressors and may represent promising targets for therapeutic interventions of brain diseases.

* Corresponding author. E-mail: dirk.hermann{at}uk-essen.de (D.M.H.); ayman.el-ali{at}crchuq.ulaval.ca (A.EA.)

Citation: D. M. Hermann, A. ElAli, The Abluminal Endothelial Membrane in Neurovascular Remodeling in Health and Disease. Sci. Signal. 5, re4 (2012).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Purification and Culture of Central Nervous System Endothelial Cells.
L. Zhou, F. Sohet, and R. Daneman (2014)
Cold Spring Harb Protoc 2014, pdb.top070987
   Abstract »    Full Text »    PDF »
Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves the Metabolic Penumbra.
A. Zechariah, A. ElAli, T. R. Doeppner, F. Jin, M. R. Hasan, I. Helfrich, G. Mies, and D. M. Hermann (2013)
Stroke 44, 1690-1697
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882