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Sci. Signal., 14 August 2012
Vol. 5, Issue 237, p. pe34
[DOI: 10.1126/scisignal.2003355]

PERSPECTIVES

L-Type Calcium Channels: On the Fast Track to Nuclear Signaling

Marianna D’Arco and Annette C. Dolphin*

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.

Abstract: Calcium signaling resulting from depolarization of neurons can trigger changes in transcription, and this response has been called excitation-transcription (E-T) coupling. In neurons, voltage-gated and ligand-gated calcium-permeable channels contribute to the increase in intracellular calcium. It appears that calcium signals mediated by specific voltage-gated calcium channels may have distinct roles in E-T coupling.

* Corresponding author. E-mail: a.dolphin{at}ucl.ac.uk

Citation: M. D’Arco, A. C. Dolphin, L-Type Calcium Channels: On the Fast Track to Nuclear Signaling. Sci. Signal. 5, pe34 (2012).

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