Science Signaling Podcast: 11 September 2012

Alissa M. Weaver¹ and Annalisa M. VanHook²

¹ Department of Cancer Biology and Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
² Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with Alissa Weaver, author of a Research Article published in the 11 September 2012 issue of Science Signaling. Metastasis is the process by which cancer cells from a primary tumor spread to a new site where they establish secondary tumors and involves cells switching between adherent and invasive states. Cells adhere to substrates through structures called focal adhesions and invade tissues using structures called invadopodia, which allow the cells to break down the extracellular matrix and penetrate tissues. Weaver’s group has combined network analysis of invadopodia and focal adhesions with data from head and neck cancers to identify key signaling molecules that influence the formation of invadopodia in invasive cancer cells.

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In Science Signaling

RESEARCH ARTICLES
Cancer
Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCα Invasive Signaling Axis

Daisuke Hoshino, Jerome Jourquin, Shane Weller Emmons, Tyne Miller, Margalit Goldgof, Kaitlin Costello, Darren R. Tyson, Brandee Brown, Yiling Lu, Nagendra K. Prasad, Bing Zhang, Gordon B. Mills, Wendell G. Yarbrough, Vito Quaranta, Motoharu Seiki, and Alissa M. Weaver (11 September 2012)
Sci. Signal. 5 (241), ra66. [DOI: 10.1126/scisignal.2002964]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PODCASTS
Cancer
Science Signaling Podcast: 26 July 2011

Sara A. Courtneidge and Annalisa M. VanHook (26 July 2011)
Sci. Signal. 4 (183), pc14. [DOI: 10.1126/scisignal.2002346]
 |  Abstract »  |  Full Text »  |  Podcast »

RESEARCH ARTICLES
Cancer
A Cell-Based High-Content Screening Assay Reveals Activators and Inhibitors of Cancer Cell Invasion

Manuela Quintavalle, Leonardo Elia, Jeffrey H. Price, Susanne Heynen-Genel, and Sara A. Courtneidge (26 July 2011)
Sci. Signal. 4 (183), ra49. [DOI: 10.1126/scisignal.2002032]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cell Biology
In Vivo Identification of Regulators of Cell Invasion Across Basement Membranes

David Q. Matus, Xiao-Yan Li, Sarah Durbin, Daniel Agarwal, Qiuyi Chi, Stephen J. Weiss, and David R. Sherwood (4 May 2010)
Sci. Signal. 3 (120), ra35. [DOI: 10.1126/scisignal.2000654]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PERSPECTIVES
Cancer
Regulation of Cancer Invasion by Reactive Oxygen Species and Tks Family Scaffold Proteins

Alissa M. Weaver (15 September 2009)
Sci. Signal. 2 (88), pe56. [DOI: 10.1126/scisignal.288pe56]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Cancer
Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

Begoña Diaz, Gidon Shani, Ian Pass, Diana Anderson, Manuela Quintavalle, and Sara A. Courtneidge (15 September 2009)
Sci. Signal. 2 (88), ra53. [DOI: 10.1126/scisignal.2000368]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »