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Sci. Signal., 9 October 2012
Vol. 5, Issue 245, p. pc22
Science Signaling Podcast: 9 October 2012
Eric J. Nestler1,2 and
Annalisa M. VanHook3
1 Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. 2 Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA. 3 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.
This Podcast features an interview with Eric Nestler, author of a Report published in the 5 October 2012 issue of Science. BDNF is a secreted ligand that stimulates the growth and survival of neurons and promotes neural plasticity, which is the phenomenon by which a neural network is altered by activity through that network and by environmental factors. Changes in BDNF expression have been linked to neurodegenerative diseases, to mood and behavioral disorders, and to neural plasticity induced by cocaine use. Nestlers group reports that whereas BDNF plays a positive role in cocaine-induced neural plasticity, it plays a negative modulatory role in morphine-induced neural plasticity and has a different site of action. These findings have implications for understanding and treating addiction and highlight the complex role of BDNF in modulating neural function through its action on multiple downstream signaling pathways.
Citation: E. J. Nestler, A. M. VanHook, Science Signaling Podcast: 9 October 2012. Sci. Signal.5, pc22 (2012).
Ja Wook Koo, Michelle S. Mazei-Robison, Dipesh Chaudhury, Barbara Juarez, Quincey LaPlant, Deveroux Ferguson, Jian Feng, Haosheng Sun, Kimberly N. Scobie, Diane Damez-Werno, Marshall Crumiller, Yoshinori N. Ohnishi, Yoko H. Ohnishi, Ezekiell Mouzon, David M. Dietz, Mary Kay Lobo, Rachael L. Neve, Scott J. Russo, Ming-Hu Han, and Eric J. Nestler (5 October 2012) Science338 (6103), 124.
[DOI: 10.1126/science.1222265] |Abstract »|Full Text »|PDF »|Supplementary Materials »