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Sci. Signal., 30 October 2012
Vol. 5, Issue 248, p. pc24
[DOI: 10.1126/scisignal.2003704]


Science Signaling Podcast: 30 October 2012

Yotis A. Senis1 and Annalisa M. VanHook2

1 Centre of Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with Yotis Senis, senior author of a Research Article published in the 30 October 2012 issue of Science Signaling. Senis’s group investigated the role of the inhibitory receptor G6b-B in platelet biology. Platelets are activated to form clots when they bind to components of the extracellular matrix (ECM) that are exposed at sites of blood vessel damage. Platelets are produced by megakaryocytes, which reside in the ECM-rich bone marrow. Despite producing the same repertoire of surface receptors as platelets, megakaryocytes are not activated by binding to ECM. Using a mouse knockout, the authors show that the inhibitory receptor G6b-B is required in megakaryocytes for the production of functional platelets, maintains megakaryoctyes in an inactive state, and keeps circulating platelets inactive until they come into contact with ECM. Mice lacking this receptor exhibited defects in platelet number, size, and function.

Citation: Y. A. Senis, A. M. VanHook, Science Signaling Podcast: 30 October 2012. Sci. Signal. 5, pc24 (2012).

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