Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 13 November 2012
Vol. 5, Issue 250, p. pe50
[DOI: 10.1126/scisignal.2003685]

PERSPECTIVES

PTEN: An Intercellular Peacekeeper?

Nick R. Leslie*

Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, James Black Centre, Dundee DD1 5EH, UK.

Abstract: It is generally assumed that cells synthesize their own intracellular enzymes. Therefore, if expression of a specific gene is silenced in a potential cancer cell, it is expected that loss of protein function will follow. A provocative study indicates an unexpected mechanism of intercellular tumor suppression, showing that PTEN (phosphatase and tensin homolog deleted from chromosome 10), a cytosolic enzyme, can be transferred between cells in exosomes to suppress signaling and proliferation in target cells.

* Corresponding author. E-mail: n.r.leslie{at}dundee.ac.uk

Citation: N. R. Leslie, PTEN: An Intercellular Peacekeeper? Sci. Signal. 5, pe50 (2012).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882