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Sci. Signal., 20 November 2012
Vol. 5, Issue 251, p. ra84
[DOI: 10.1126/scisignal.2003431]

RESEARCH ARTICLES

SUMOylation Silences Heterodimeric TASK Potassium Channels Containing K2P1 Subunits in Cerebellar Granule Neurons

Leigh D. Plant1, Leandro Zuniga1, Dan Araki1, Jeremy D. Marks2, and Steve A. N. Goldstein1*

1 Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.
2 Department of Pediatrics and Institute for Molecular Pediatrics Sciences, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.

Abstract: The standing outward K+ current (IKso) governs the response of cerebellar granule neurons to natural and medicinal stimuli including volatile anesthetics. We showed that SUMOylation silenced half of IKso at the surface of cerebellar granule neurons because the underlying channels were heterodimeric assemblies of K2P1, a subunit subject to SUMOylation, and the TASK (two–P domain, acid-sensitive K+) channel subunits K2P3 or K2P9. The heterodimeric channels comprised the acid-sensitive portion of IKso and mediated its response to halothane. We anticipate that SUMOylation also influences sensation and homeostatic mechanisms in mammals through TASK channels formed with K2P1.

* To whom correspondence should be addressed. E-mail: goldstein{at}brandeis.edu

Citation: L. D. Plant, L. Zuniga, D. Araki, J. D. Marks, S. A. N. Goldstein, SUMOylation Silences Heterodimeric TASK Potassium Channels Containing K2P1 Subunits in Cerebellar Granule Neurons. Sci. Signal. 5, ra84 (2012).

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