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Sci. Signal., 5 February 2013
Vol. 6, Issue 261, p. pc4
[DOI: 10.1126/scisignal.2003978]


Science Signaling Podcast: 5 February 2013

Felix Randow1 and Annalisa M. VanHook2

1 MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Hills Road, Cambridge CB2 0QH, UK.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with Felix Randow, senior author of a Research Article that appears in the 5 February 2013 issue of Science Signaling. Intracellular pathogens such as Salmonella damage vesicular membranes in infected cells. The cargo receptor NDP52 drives selective autophagy of Salmonella and the damaged vesicles with which it is associated. NDP52 detects Salmonella infection by binding to galectin-8, a host protein that is recruited to membranes damaged by the pathogen. By solving the crystal structure of NDP52 in complex with galectin-8, Li et al. revealed how NDP52 stimulates selective autophagy in response to infection by Salmonella.

Citation: F. Randow, A. M. VanHook, Science Signaling Podcast: 5 February 2013. Sci. Signal. 6, pc4 (2013).

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