Sci. Signal., 12 February 2013
Science Signaling Podcast: 12 February 2013
Gregg L. Semenza1,2,3,4,5, Maimon E. Hubbi1,2, and Annalisa M. VanHook6
1 Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Abstract: This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1–mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the α subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.
Citation: G. L. Semenza, M. E. Hubbi, A. M. VanHook, Science Signaling Podcast: 12 February 2013. Sci. Signal. 6, pc5 (2013).
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