Science Signaling Podcast: 12 February 2013

Gregg L. Semenza^1,2,3,4,5, Maimon E. Hubbi^1,2, and Annalisa M. VanHook⁶

¹ Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
³ Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁴ Departments of Medicine and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁵ Departments of Pediatrics and Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁶ Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1–mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the α subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH ARTICLES
Cell Biology
A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication

Maimon E. Hubbi, Kshitiz, Daniele M. Gilkes, Sergio Rey, Carmen C. Wong, Weibo Luo, Deok-Ho Kim, Chi V. Dang, Andre Levchenko, and Gregg L. Semenza (12 February 2013)
Sci. Signal. 6 (262), ra10. [DOI: 10.1126/scisignal.2003417]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PERSPECTIVES
Development
HIF Takes It Up a Notch

Eric A. Johnson (12 July 2011)
Sci. Signal. 4 (181), pe33. [DOI: 10.1126/scisignal.2002277]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Hypoxia
mAKAP Compartmentalizes Oxygen-Dependent Control of HIF-1

Wei Wong, April S. Goehring, Michael S. Kapiloff, Lorene K. Langeberg, and John D. Scott (23 December 2008)
Sci. Signal. 1 (51), ra18. [DOI: 10.1126/scisignal.2000026]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »