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Sci. Signal., 19 February 2013
Vol. 6, Issue 263, p. pc6
[DOI: 10.1126/scisignal.2004006]

PODCASTS

Science Signaling Podcast: 19 February 2013

Jayne S. Danska1,2,3 and Annalisa M. VanHook4

1 Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1X8, Canada.
2 Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
3 Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada.
4 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with Jayne Danska, senior author of a paper that was released on Science Express on 17 January 2013. A group led by Danska has uncovered an interaction between the gut microbiota and sex hormones that influences the development of type 1 diabetes in mice. Although type 1 diabetes shows no sex bias in humans, females of the non-obese diabetic (NOD) mouse strain are about twice as likely to develop the disease as are NOD males. Markle et al. report that male-type gut microbiota were associated with an increase in testosterone that reduces an individual's chances of developing type 1 diabetes. This protection was prevented by interfering with testosterone signaling.

Citation: J. S. Danska, A. M. VanHook, Science Signaling Podcast: 19 February 2013. Sci. Signal. 6, pc6 (2013).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882