Sci. Signal., 19 February 2013
Science Signaling Podcast: 19 February 2013
Jayne S. Danska1,2,3 and Annalisa M. VanHook4
1 Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1X8, Canada.
Abstract: This Podcast features an interview with Jayne Danska, senior author of a paper that was released on Science Express on 17 January 2013. A group led by Danska has uncovered an interaction between the gut microbiota and sex hormones that influences the development of type 1 diabetes in mice. Although type 1 diabetes shows no sex bias in humans, females of the non-obese diabetic (NOD) mouse strain are about twice as likely to develop the disease as are NOD males. Markle et al. report that male-type gut microbiota were associated with an increase in testosterone that reduces an individual's chances of developing type 1 diabetes. This protection was prevented by interfering with testosterone signaling.
Citation: J. S. Danska, A. M. VanHook, Science Signaling Podcast: 19 February 2013. Sci. Signal. 6, pc6 (2013).
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